![]() ![]() Contraction strength is directly proportional to intracellular calcium concentration, allowing actin and myosin to interact. ![]() Calcium entry during the plateau phase of the action potential in myocardial cells releases calcium from the sarcoplasmic reticulum to the cytosol, triggering myocardial contraction. L type voltage-gated calcium channels are predominant in the following sites and roles:ĭepolarization of the sinoatrial node (SA) and impulse propagation through the atrioventricular node (AV). Calcium channel blockers in all their subtypes target the L-type voltage-gated calcium channels. ![]()
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